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Is There A Gene Identified For Vitiligo?

A MyVitiligoTeam Member asked a question 💭
Colorado Springs, CO
January 11
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A MyVitiligoTeam Member

Joe6 hello and I hope you're doing well! I'm fine and having a great weekend! In respond to your question I found the following online as written below:
Yes, some candidate genes
have been identified that are associated with vitiligo, including:
HLA, AIRE, VIT1, CAT, FOXD3, ESR1, COMT, PTPNN22, NALP1, PDGFRA, MYG1, MITF, CD117, XBP1, FAS, COX2, EDN1, and ACE.
Vitiligo is a skin disease
that causes a progressive loss of melanocytes, leading to white patches on the body. The variations in the NLRP1 and PTPN22 genes are associated with an increased risk of developing vitiligo. These variations may affect the activity of the NLRP1 and PTPN22 proteins, making it more difficult for the body to control inflammation and prevent the immune system from attacking its own tissues.
Genetics play a role in vitiligo, as it is more common in family members of people with vitiligo.
This is for informational purposes only. This information does not constitute medical advice or diagnosis. 😀

March 23
A MyVitiligoTeam Member

Good question! I found the following. Hope it helps.

XBP1 gene is considered to be a candidate gene for vitiligo due to its plausible role in the onset of the disease through its interaction with HLA-DR, (79) however, clearly warrants further study.

Source:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC35....

January 12

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